Bioengineered heparins and heparan sulfates
نویسندگان
چکیده
منابع مشابه
Bioengineered heparins and heparan sulfates.
Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells. While heparan sulfate is a widely distributed membrane and extracellular glycosaminoglycan, ...
متن کاملHeparins and heparan sulfates. Structure, distribution and protein interactions
Sulfated glycosaminoglycans are absent in protista, plantae and fungi. In the animal kingdom, the appearance of heparan sulfate coincides with the emergence of eumetazoa, which are animals that display true tissues. These compounds are ubiquitously found in the cell surface of all tissues and species. On the other hand, the distribution of heparin is scattered In honor of Prof. Carl P. Dietrich...
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The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the fo...
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Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine. This study explored the effect of different bioreactor conditions on the production of heparin/heparan sulfate chains via the recombinant expression of serglycin in mammalian cells. Tissue culture flasks and continuously-stirred tank reac...
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Heparan sulfates (HS), a class of glycosaminoglycans, are long linear complex polysaccharides covalently attached to a protein core. The HS molecules are made up of repeating disaccharides onto which modification patterns are superimposed. This results in a large structural heterogeneity and forms the basis of specific interactions of HS toward a vast array of proteins, including growth factors...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2016
ISSN: 0169-409X
DOI: 10.1016/j.addr.2015.11.002